[HTML][HTML] Comprehensive proteomic signature and identification of CDKN2A as a promising prognostic biomarker and therapeutic target of colorectal cancer

QQ Wang, YC Zhou, YJZ Ge, G Qin, TF Yin… - World journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND The carcinogenesis of colorectal cancer (CRC) involves many different
molecules and multiple pathways, and the specific mechanism has not been elucidated until …

Identification of colon tumor marker NKD1 via integrated bioinformatics analysis and experimental validation

Y Wang, C Yang, W Li, Y Shen, J Deng, W Lu… - Cancer …, 2021 - Wiley Online Library
Background Colorectal cancer is an important death‐related disease in the worldwide.
However, specific colon cancer tumor markers currently used for diagnosis and treatment …

[HTML][HTML] High expression of CDKN2A is associated with poor prognosis in colorectal cancer and may guide PD-1-mediated immunotherapy

Y Dong, M Zheng, X Wang, C Yu, T Qin, X Shen - BMC cancer, 2023 - Springer
Background Colorectal cancer (CRC) is one of the most common malignancies worldwide.
Immunotherapy targeting the programmed death protein 1 (PD-1) and its ligand (PD-L1), is a …

[HTML][HTML] Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network

H Zhu, Y Ji, W Li, M Wu - Oncology Letters, 2019 - spandidos-publications.com
The aim of the present study was to identify key genes in colorectal cancer (CRC) that could
be used to reliably diagnose this disease and to explore the potential underlying …

[HTML][HTML] The cell cycle-associated protein CDKN2A may promotes colorectal cancer cell metastasis by inducing epithelial-mesenchymal transition

WK Shi, YH Li, XS Bai, GL Lin - Frontiers in Oncology, 2022 - frontiersin.org
Colorectal cancer (CRC) is a common gastrointestinal malignancy, and recurrence and
metastasis contribute considerably to its high mortality. It is well known that the epithelial …

KCND2: a prognostic biomarker and regulator of immune function in gastric cancer

H Zhou, D Su, Y Chen, Y Zhang, P Huang - Cancer Medicine, 2023 - Wiley Online Library
Background Gastric cancer is a highly heterogeneous disease, which makes it challenging
to develop effective targeted therapies. Although the potassium voltage‐gated channel …

Selection of putative colorectal cancer markers by applying PCA on the soluble proteome of tumors: NDK A as a promising candidate

P Álvarez-Chaver, AM Rodríguez-Piñeiro… - Journal of …, 2011 - Elsevier
Aiming to find new tumor markers for colorectal cancer (CRC), we applied proteomic
methodologies to compare the soluble sub-proteome of healthy and tumoral colorectal …

High KCNQ1OT1 Expression Might Independently Predict Shorter Survival of Colon Adenocarcinoma

K Zhang, J Yan, B Yi, Y Rui, H Hu - Future Oncology, 2019 - Taylor & Francis
Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and
rectal adenocarcinoma (COAD and READ) separately. Patients & methods …

[HTML][HTML] KCNN4 is a potential biomarker for predicting cancer prognosis and an essential molecule that remodels various components in the tumor microenvironment …

S Chen, X Su, Z Mo - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Objectives: Potassium Calcium-Activated Channel Subfamily N Member 4 (KCNN4) is a
member of the KCNN family. Studies have revealed that KCNN4 is implicated in various …

[HTML][HTML] Influential upregulation of KCNE4: Propelling cancer associated fibroblasts-driven colorectal cancer progression

Z Zhang, S Liu, Z Wang, S Wang, L Jiang… - Cancer Cell …, 2024 - Springer
Background Colorectal cancer (CRC) is a malignancy of remarkable heterogeneity and
heightened morbidity. Cancer associated fibroblasts (CAFs) are abundant in CRC tissues …