Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …

Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

There is increasing recognition that three-dimensional (3D) tissue culture technologies have
many uses within the biomedical sciences beyond the scope of regenerative medicine. One …

Classically, most cell culture experiments have been performed under adherent 2D
conditions. Cells in the human body grow within an organized 3D matrix, surrounded by …

Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical
models. There is a growing realization that the tumor microenvironment is a critical …

In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …

Abstract Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three
dimensional (3D) architecture and complexity of human tumors. More representative models …