Using an integrated approach to characterize the pancreatic tissue and isolated islets from a
33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β …

Mutations in hepatocyte nuclear factor 1α (HNF-1 α) lead to maturity-onset diabetes of the
young type 3 as a result of impaired insulin secretory response in pancreatic β-cells. The …

Maturity onset diabetes of the young (MODY) is a heterogenous, monogenic disease that is
characterized by an autosomal dominant inheritance and an early disease onset, usually …

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …

The reverse tetracycline‐dependent transactivator system was employed in insulinoma INS‐
1 cells to achieve controlled inducible expression of hepatocyte nuclear factor‐1α (HNF1α) …

We used transgenesis to explore the requirement for downregulation of hepatocyte nuclear
factor 6 (HNF6) expression in the assembly, differentiation, and function of pancreatic islets …

One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the
gene encoding hepatocyte nuclear factor (HNF)-1α. We generated transgenic mice …

The transcription of individual genes is determined by combinatorial interactions between
DNA–binding transcription factors. The current challenge is to understand how such …

Heterozygous mutations in the genes encoding transcriptional regulators hepatocyte
nuclear factor (HNF)-1α and HNF-4α cause a form of diabetes known as maturity-onset …

Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and HNF-1α impair
insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4α is known …