From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …

αIIbβ3, the major membrane protein on the surface of platelets, is a member of the integrin
family of heterodimeric adhesion receptors. The αIIb and β3 subunits are each composed of …

Objective—Integrins are attractive therapeutic targets. Inhibition of integrin αIIbβ3 effectively
blocks platelet aggregation. However, limitations with intravenous αIIbβ3 antagonists and …

Cell adhesion, which plays a major role in the response of tissues to injury, involves a wide
variety of cells, adhesion receptors, and ligands. Prominent among the cells responding to …

Platelets are critical for the maintenance of the integrity of the vascular system and are the
first line of defence against haemorrhage. When they encounter a subendothelial matrix …

Background—Large, randomized, and blinded clinical trials (EPIC, EPILOG, and CAPTURE)
have demonstrated that abciximab (ReoPro, chimeric 7E3 Fab) markedly reduces …

Abciximab, a derivative of the murine mAb 7E3, protects against ischemic complications of
percutaneous coronary interventions by inhibiting ligand binding to the αIIbβ3 receptor. In …

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma
and the extracellular matrices (ECMs) that are essential for platelet adhesion and …

Intracellular signals are received and generated by the αIIbβ3 integrin on platelets. Recent
advances have been made in the areas of agonist receptors that initiate platelet activation …

Integrin α IIb β 3 plays a critical role in platelet aggregation, a central response in
hemostasis and thrombosis. This function of α IIb β 3 depends upon a transition from a …