Diabetic nephropathy (DN) is a severe complication of prolonged diabetes, impacting
millions worldwide with an increasing incidence. This study investigates the role of tribbles …

Background Renal fibrosis is thought to be the common pathway in most cases of chronic
kidney disease. Recently, TRIB3 was found to play an important role in progression of …

To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of
type 2 diabetic nephropathy, we used immunohistochemistry, real‐time quantitative PCR …

Tribbles homolog 3 (TRIB3) is an intracellular kinase-like molecule that modifies cellular
survival and metabolism. The present study aimed to investigate the function of TRIB3 …

The endoplasmic reticulum (ER) stress response is activated in the diabetic kidney and
functions to reduce ER protein accumulation and improve cellular function. We previously …

Objective To examine the effect of TRIB3 on endoplasmic reticulum stress induced β-cell
apoptosis and to investigate the mechanism with a specific emphasis on the role of NF-κB …

Glucose deprivation occurs in several human diseases, including infarctions and solid
tumors, and leads to cell death. In this article, we investigate the role of the pseudokinase …

Obesity caused by excess feeding (overnutrition) has become a problem of epidemic
proportions and is the underlying cause in metabolic disorders and chronic diseases such …

Objective Macrophage-mediated inflammation plays a significant role in the development
and progression of diabetic nephropathy (DN). However, the underlying mechanisms …

Diabetic nephropathy (DN) is one of the most common complications of diabetes. Gradual
loss of podocytes is a sign of DN and pyroptosis mechanistically correlates with podocyte …