SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression
To understand the molecular association between inflammation and dysregulated
metabolism in glioblastoma, the effect of IL-1β on Hexokinase 2 (HK2) expression was …
metabolism in glioblastoma, the effect of IL-1β on Hexokinase 2 (HK2) expression was …
Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells
Z Dong, X Zhong, Q Lei, F Chen, H Cui - Cellular Signalling, 2019 - Elsevier
Glioblastoma (GBM) is the most aggressive and malignant form of brain tumors. However, its
molecular mechanisms of tumorigenesis and cancer development remains to elucidate …
molecular mechanisms of tumorigenesis and cancer development remains to elucidate …
SIRT3 functions in the nucleus in the control of stress-related gene expression
T Iwahara, R Bonasio, V Narendra… - Molecular and cellular …, 2012 - Taylor & Francis
SIRT3 is a member of the Sir2 family of NAD+-dependent protein deacetylases that
promotes longevity in many organisms. The processed short form of SIRT3 is a well …
promotes longevity in many organisms. The processed short form of SIRT3 is a well …
Hexokinase 2 and nuclear factor erythroid 2–related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells
A dynamic network of metabolic adaptations, inflammatory responses, and redox
homeostasis is known to drive tumor progression. A considerable overlap among these …
homeostasis is known to drive tumor progression. A considerable overlap among these …
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
A Vaquero, M Scher, D Lee, H Erdjument-Bromage… - Molecular cell, 2004 - cell.com
We characterized human SirT1, one of the human homologs of the budding yeast Sir2p, an
NAD+-dependent histone deacetylase involved in establishing repressive chromatin and …
NAD+-dependent histone deacetylase involved in establishing repressive chromatin and …
Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization
RI Tennen, E Berber, KF Chua - Mechanisms of ageing and development, 2010 - Elsevier
The mammalian sirtuin SIRT6 is a site-specific histone deacetylase that regulates chromatin
structure. SIRT6 is implicated in fundamental biological processes in aging, including …
structure. SIRT6 is implicated in fundamental biological processes in aging, including …
Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia
OH Lee, J Kim, JM Kim, H Lee, EH Kim, SK Bae… - Biochemical and …, 2013 - Elsevier
Abstract Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD+-dependent deacetylases and
has been implicated in the regulation of metabolism, inflammation, and aging. Here, we …
has been implicated in the regulation of metabolism, inflammation, and aging. Here, we …
IGF-1 induced HIF-1α-TLR9 cross talk regulates inflammatory responses in glioma
The insulin-like growth factor (IGF-1) induces hypoxia inducible factor (HIF-1α) regulated
genes in glioblastoma multiforme (GBM). As HIF-1α links inflammatory and oncogenic …
genes in glioblastoma multiforme (GBM). As HIF-1α links inflammatory and oncogenic …
C/EBPα negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular carcinoma cells
G Liu, J Lu, Y Zhang, L Zhang, G Lu, Z Xie… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Mammalian Sirtuin proteins (SIRTs) are homologs of yeast Sir2, and characterized
as class III histone deacetylases of NAD+ dependence. Unlike their lower counterparts that …
as class III histone deacetylases of NAD+ dependence. Unlike their lower counterparts that …
SIRT1‐SIRT3 axis regulates cellular response to oxidative stress and etoposide
I Carnevale, L Pellegrini, P D'Aquila… - Journal of Cellular …, 2017 - Wiley Online Library
Sirtuins are conserved NAD+‐dependent deacylases. SIRT1 is a nuclear and cytoplasmic
sirtuin involved in the control of histones a transcription factors function. SIRT3 is a …
sirtuin involved in the control of histones a transcription factors function. SIRT3 is a …