To understand the molecular association between inflammation and dysregulated
metabolism in glioblastoma, the effect of IL-1β on Hexokinase 2 (HK2) expression was …

Glioblastoma (GBM) is the most aggressive and malignant form of brain tumors. However, its
molecular mechanisms of tumorigenesis and cancer development remains to elucidate …

SIRT3 is a member of the Sir2 family of NAD+-dependent protein deacetylases that
promotes longevity in many organisms. The processed short form of SIRT3 is a well …

A dynamic network of metabolic adaptations, inflammatory responses, and redox
homeostasis is known to drive tumor progression. A considerable overlap among these …

We characterized human SirT1, one of the human homologs of the budding yeast Sir2p, an
NAD+-dependent histone deacetylase involved in establishing repressive chromatin and …

The mammalian sirtuin SIRT6 is a site-specific histone deacetylase that regulates chromatin
structure. SIRT6 is implicated in fundamental biological processes in aging, including …

Abstract Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD+-dependent deacetylases and
has been implicated in the regulation of metabolism, inflammation, and aging. Here, we …

The insulin-like growth factor (IGF-1) induces hypoxia inducible factor (HIF-1α) regulated
genes in glioblastoma multiforme (GBM). As HIF-1α links inflammatory and oncogenic …

Abstract Mammalian Sirtuin proteins (SIRTs) are homologs of yeast Sir2, and characterized
as class III histone deacetylases of NAD+ dependence. Unlike their lower counterparts that …

Sirtuins are conserved NAD+‐dependent deacylases. SIRT1 is a nuclear and cytoplasmic
sirtuin involved in the control of histones a transcription factors function. SIRT3 is a …