Systemic sclerosis (SSc) is an autoimmune disease with a poor prognosis. To date, the
pathogenesis of SSc is still unclear; moreover, its pathological conditions include …

A better understanding of SSc pathogenesis will allow the development of novel therapeutic
strategies targeting specific cell types and the pathways that are abnormally activated as …

Systemic sclerosis (SSc) is a rare autoimmune disease that is characterized by fibrosis,
inflammation, and vasculopathy of the skin and internal organs. The etiopathogenesis of …

Systemic sclerosis (SSc) is an autoimmune connective tissue disease that is characterized
by vasculopathy and excessive deposition of extracellular matrix, which causes fibrosis of …

Despite long-standing recognition of the importance of T cells in systemic sclerosis (SSc;
scleroderma), the role of CD8+ T cells in disease pathogenesis has not been well studied …

We investigated in systemic sclerosis (SSc) patients the T cell homeostasis and its
relationship with the clinical course of the disease. Distribution of peripheral T cell subsets …

Although the pathogenesis of systemic sclerosis (SSc) remains unknown, cytokine
production and release are key events in this autoimmune disease, characterized by T cell …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Over the last decade, it has become clear that an activated immune system plays a central
role in causing tissue damage in patients with systemic sclerosis (SSc). What remains …

We propose to approach SSc as a multistep immune-mediated disease that is in need of a
therapeutic strategy designed to interfere with one or more of these aberrant molecular …