The irradiated cercariae vaccine model: looking on the bright side of radiation
D Richter, DA Harn, FR Matuschka - Parasitology today, 1995 - cell.com
Schistosovnes infect between 200 and 300 million people at any one time. A lnajor strategy
to reduce the ivnpact of schistosovniasis on human health is the developvnent of a defined …
to reduce the ivnpact of schistosovniasis on human health is the developvnent of a defined …
The radiation-attenuated vaccine against schistosomes in animal models: paradigm for a human vaccine?
PS Coulson - Advances in parasitology, 1997 - Elsevier
Publisher Summary Schistosomes can be established in the mammalian host; cercariae
must penetrate the skin, transform into schistosomula, locate their favored site in the …
must penetrate the skin, transform into schistosomula, locate their favored site in the …
Comparison of irradiated-cercaria schistosome vaccine models that use 15-and 50-kilorad doses: the 15-kilorad dose gives greater protection, smaller liver sizes, and …
SR Reynolds, DA Harn - Infection and Immunity, 1992 - Am Soc Microbiol
The protection and immune response to infection caused by the parasite Schistosoma
mansoni were studied by comparison of two murine irradiated-vaccine models. Mice were …
mansoni were studied by comparison of two murine irradiated-vaccine models. Mice were …
Vaccination of mice with γ‐irradiated Schistosoma japonicum cercariae
Y ZHANG, MG TAYLOR, QD BICKLE… - Parasite …, 1999 - Wiley Online Library
γ‐irradiated cercarial vaccines induce high levels of protection in mice against Schistosoma
mansoni infection, however, the same has not been well established for S. japonicum. Here …
mansoni infection, however, the same has not been well established for S. japonicum. Here …
Candidate vaccine antigens identified by antibodies from mice vaccinated with 15-or 50-kilorad-irradiated cercariae of Schistosoma mansoni
D Richter, DA Harn - Infection and Immunity, 1993 - Am Soc Microbiol
In murine schistosomiasis, the highest levels of resistance to cercarial challenge are
obtained by vaccination with radiation-attenuated cercariae. To identify candidate vaccine …
obtained by vaccination with radiation-attenuated cercariae. To identify candidate vaccine …
A biological and immunological comparison of Chinese and Philippine Schistosoma japonicum
M Hope, M Duke, DP McManus - International journal for parasitology, 1996 - Elsevier
A comparison was made of the host (BALB c mice)-parasite relationship of a Chinese
mainland (Anhui) strain and Philippine (Sorsogon) strain of Schistosoma japonicum …
mainland (Anhui) strain and Philippine (Sorsogon) strain of Schistosoma japonicum …
[HTML][HTML] A meta-analysis of experimental studies of attenuated Schistosoma mansoni vaccines in the mouse model
M Fukushige, KM Mitchell, CD Bourke… - Frontiers in …, 2015 - frontiersin.org
Schistosomiasis is a water-borne, parasitic disease of major public health importance. There
has been considerable effort for several decades toward the development of a vaccine …
has been considerable effort for several decades toward the development of a vaccine …
[HTML][HTML] Why the radiation-attenuated cercarial immunization studies failed to guide the road for an effective schistosomiasis vaccine: A review
Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus
Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma …
Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma …
Protective immunity to Schistosoma mansoni induced in the olive baboon Papio anubis by the irradiated cercaria vaccine
The radiation-attenuated schistosome vaccine induces a high level of protective immunity in
rodents. In order to assess its potential relevance to man, we have tested its efficacy in the …
rodents. In order to assess its potential relevance to man, we have tested its efficacy in the …
Schistosoma mansoni: Is acquired immunity induced by highly X-irradiated cercariae dependent on the size of the challenging dose?
SYL Hsü, HF Hsü, JW Osborne, SC Johnson - The Journal of Parasitology, 1982 - JSTOR
A high degree of immunity, as shown by a 91% reduction of the number of worms recovered
was found in five groups of mice that were immunized five times with highly X-irradiated …
was found in five groups of mice that were immunized five times with highly X-irradiated …