The aging of bone marrow (BM) remains a very imperative and alluring subject, with an ever-
increasing interest among fellow scientists. A considerable amount of progress has been …

Recent technological advances that allow faster and cheaper DNA sequencing are now
driving biological and medical research. In this review, we provide an overview of state-of …

Ageing is the part of natural biology lifespan and living pathology healthspan that is
associated with impact from stress, environmental changes and diseases. The present …

As the demographic structure shifts towards an aging society, strategies aimed at slowing
down or reversing the aging process become increasingly essential. Aging is a major …

Aging, chronic inflammation, and environmental insults play an important role in a number of
disease processes through alterations of the epigenome. In this review we explore how age …

Single-cell transcriptomic technologies enable the uncovering and characterization of
cellular heterogeneity and pave the way for studies aiming at understanding the origin and …

Advancing age is associated with several age-related diseases (ARDs), with
musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic …

So far, the investigation of stem cell aging has been primarily carried out at the genomic
level to follow transcriptome changes, clonal dominance, epigenetic changes, and, more …

Human lifespan is now longer than ever and, as a result, modern society is getting older.
Despite that, the detailed mechanisms behind the ageing process and its impact on various …

Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …