Highlights•Intrathecal injection DAPT suppressed Notch signaling and relieved vincristine-
induced neuropathic pain.•Inactivated Notch signaling could suppress microglial …

Paclitaxel-induced neuropathic pain (PINP) is a progressive and refractory side effect of
chemotherapy with few effective treatments at present. It is well-established that astrocytes …

Abstract Background The Notch signaling pathway has been shown to be involved in the
development of the nervous system. Recent studies showed that Notch receptors and …

Background Nerve injury-induced neuropathic pain is a major health problem worldwide.
Notch signaling is a highly conserved pathway in evolution, which has an important role in …

Neuropathic pain is a major health problem caused by dysfunction or damage of the nerve
fibers in the peripheral or central nervous system. Notch signaling is a highly conserved …

Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity
caused by peripheral nerves injury. The Notch signaling pathway has been shown to …

We studied the effects of minocycline (an inhibitor of microglial activation) on the expression
and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline …

Understanding the interactions between Notch1 and toll-like receptor 4 (TLR4) signaling
pathways in the development of diabetic peripheral neuropathy may lead to interpretation of …

This study is intended to explore the mechanism that lidocaine ameliorates chronic
constriction injury (CCI)-induced neuropathic pain (NP) related to the polarization of M1 and …

Chemotherapy-induced peripheral neuropathy (CIPN) is the most common side-effect of anti-
cancer therapy. To date, there are no clinically effective analgesics that could prevent and …