Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

Cytochrome P450 and other families of drug-metabolizing enzymes are commonly thought
of and studied for their ability to metabolize xenobiotics and other foreign entities as they are …

The bioactivation of drugs is often associated with toxicological outcomes; however, for most
cases, the causal relationship between bioactivation and toxicity is not well established …

The P450 type cytochromes are responsible for the metabolism of a wide variety of
xenobiotics and endogenous compounds. Although P450-catalyzed reactions are generally …

Cytochrome P450 constitute a superfamily of heme-containing enzymes that catalyze the
oxidative biotransformation of structurally diverse xenobiotics including drugs. Inhibition of …

Abstract The cytochrome P450 (P450) enzymes are the major catalysts involved in the
metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug …

Oxidative metabolism is one of the major biotransformation reactions that regulates the
exposure of xenobiotics and their metabolites in the circulatory system and local tissues and …

The cytochrome P450 (CYP) enzyme family is the major enzyme system catalyzing the
phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in the …

The development of the cytochrome P450 (P450) field has been remarkable in the areas of
pharmacology and toxicology, particularly in drug development. Today it is possible to use …