The pathogenesis of ischemia–reperfusion acute lung injury (IR-ALI) is not yet fully
understood. We previously reported that unwonted increased type 2 immunity plays a key …

The objective of the study is to investigate the role and specific molecular mechanism of
interleukin-33 (IL-33) acted on acute lung injury (ALI) induced by lipopolysaccharide (LPS) …

Objective The mechanisms of lung injury in acute respiratory distress syndrome (ARDS) are
not well understood. Piezo1 was recently identified as a mechanotransduction protein. The …

Introduction Pulmonary fibrosis is a major cause of the poor prognosis of acute respiratory
distress syndrome (ARDS). While mechanical ventilation (MV) is an indispensable life …

Deregulation of the immune system in sepsis plays the central role in the pathogenesis of
multiple organ failure including septic lung injury. Group 2 innate lymphoid cells (ILC2s) …

Background Pulmonary inflammation and endothelial barrier permeability increase in acute
lung injury (ALI) and acute respiratory distress syndrome (ARDS) induced by pro …

Tissue infiltration by circulating monocytes is a critical step in the initiation and augmentation
of type 2 inflammatory responses in the lungs. Our studies demonstrate that IL-33−/− mice …

Acute respiratory distress syndrome is an often fatal disease that develops after acute lung
injury and trauma. How released tissue damage signals, or alarmins, orchestrate early …

Objective This study aimed to investigate the role of endothelial Piezo1 in mediating
ventilator-induced lung injury secondary to acute respiratory distress syndrome (ARDS) …

Cardiac dysfunction is a well-recognized complication of sepsis and is associated with the
outcome and prognosis of septic patients. Evidence suggests that Il12a participates in the …