[HTML][HTML] Cell-by-Cell: Unlocking lung cancer pathogenesis

A Sinjab, Z Rahal, H Kadara - Cancers, 2022 - mdpi.com
Simple Summary Advances in lung cancer screening have led to a growing need for early
intervention strategies for the expanding cohort of patients being diagnosed with the number …

Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Z Megyesfalvi, S Heeke, BJ Drapkin, A Solta, I Kovacs… - Cancer cell, 2023 - cell.com
The understanding of small cell lung cancer (SCLC) biology has increased dramatically in
recent years, but the processes that allow SCLC to progress rapidly remain poorly …

[HTML][HTML] Developmental insights into lung cancer

TJ Desai - Annual review of cancer biology, 2021 - annualreviews.org
Lung cancer continues to be the number one cancer killer. Despite a surge of therapeutic
advances in recent years, lung cancer remains fatal when it presents at a stage too …

[HTML][HTML] Untangling the evolutionary roots of lung cancer

S Devarakonda, R Govindan - Nature communications, 2019 - nature.com
The genomic and host factors that drive the progression of pre-invasive lesions in non-small
cell lung cancer are poorly understood. Studying these factors can advance our knowledge …

Epithelial cell plasticity defines heterogeneity in lung cancer

P Sarode, S Mansouri, A Karger, MB Schaefer… - Cellular …, 2020 - Elsevier
Lung cancer is the leading cause of cancer death for both men and women and accounts for
almost 18.4% of all deaths due to cancer worldwide, with the global incidence increasing by …

[HTML][HTML] Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights

S Renaut, V Saavedra Armero, DK Boudreau… - PLoS …, 2024 - journals.plos.org
Whether single-cell RNA-sequencing (scRNA-seq) captures the same biological information
as single-nucleus RNA-sequencing (snRNA-seq) remains uncertain and likely to be context …

Analytic inquiry: molecular testing in lung cancer

MF Zakowski - Cancer Cytopathology, 2017 - Wiley Online Library
Non‐small cell lung cancer is a different disease from what it was a decade ago. The last 10
years were based on remarkable advances in the understanding of key genetic alterations …

[HTML][HTML] Deciphering the Immune–Tumor Interplay During Early-Stage Lung Cancer Development via Single-Cell Technology

WW Chen, W Liu, Y Li, J Wang, Y Ren, G Wang… - Frontiers in …, 2022 - frontiersin.org
Lung cancer is the leading cause of cancer-related death worldwide. Cancer
immunotherapy has shown great success in treating advanced-stage lung cancer but has …

[HTML][HTML] Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

F Wu, J Fan, Y He, A Xiong, J Yu, Y Li, Y Zhang… - Nature …, 2021 - nature.com
Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …

[HTML][HTML] Lung adenocarcinoma tumor origin: a guide for personalized medicine

L Seguin, M Durandy, CC Feral - Cancers, 2022 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer-related death worldwide, with
an average 5-year survival rate of approximately 15%. Among the multiple histological type …