Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
[HTML][HTML] Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice
A subset of individuals infected with HIV-1 develops broadly neutralizing antibodies (bNAbs)
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice
CA Cottrell, X Hu, JH Lee, P Skog, S Luo… - Science Translational …, 2024 - science.org
A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs).
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
A major goal of HIV-1 vaccine research is the design of immunogens capable of inducing
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …
Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env
A Escolano, HB Gristick, R Gautam… - Science translational …, 2021 - science.org
Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and
antibody coevolution. Previous studies showed that sequential immunization with a V3 …
antibody coevolution. Previous studies showed that sequential immunization with a V3 …
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
M Bonsignori, EF Kreider, D Fera… - Science translational …, 2017 - science.org
A preventive HIV-1 vaccine should induce HIV-1–specific broadly neutralizing antibodies
(bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to …
(bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to …
[HTML][HTML] Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with> 50% breadth
Vaccine elicitation of broadly neutralizing antibodies (bnAbs) is a key HIV-research goal.
The VRC01 class of bnAbs targets the CD4-binding site on the HIV-envelope trimer and …
The VRC01 class of bnAbs targets the CD4-binding site on the HIV-envelope trimer and …
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope
(Env) trimer are the most common bnAbs induced during infection, making them promising …
(Env) trimer are the most common bnAbs induced during infection, making them promising …