Although regulatory T cells (Tregs) are well described, identifying autoaggressive effector T
cells has proven more difficult. However, we identified CD4loCD40+ (Th40) cells as being …

The role of regulatory T cells (Tregs) in maintaining self tolerance has been intensively
researched and there is a growing consensus that a decline in Treg function is an important …

Previous results have shown that CD4+ CD25+ regulatory T cells (Tregs) control
autoimmunity in a spontaneous model of type 1 diabetes, the nonobese diabetic (NOD) …

Nonobese diabetic (NOD) mice serve as a model of spontaneous type 1 diabetes (T1D), a T
cell‐mediated autoimmune disease leading to the destruction of pancreatic insulin …

Biobreeding (BB) rats model type 1 autoimmune diabetes (T1D). BB diabetes-prone (BBDP)
rats develop T1D spontaneously. BB diabetes-resistant (BBDR) rats develop T1D after …

OBJECTIVE—In this study, we asked whether a possible quantitative or qualitative
deficiency in naturally occurring Foxp3+ CD4+ regulatory T-cells (nTreg), which display …

FoxP3+ CD4+ regulatory T cells (Tregs) play a key role in the maintenance of peripheral self-
tolerance, and it has been suggested that diabetes-susceptible nonobese diabetic (NOD) …

CD4+ CD25+ Foxp3+ regulatory T cells (T regs) are important for preventing autoimmune
diabetes and are either thymic-derived (natural) or differentiated in the periphery outside the …

Regulatory T cell (Treg) insufficiency licenses the destruction of insulin-producing pancreatic
β-cells by autoreactive effector T cells (Teffs), causing spontaneous autoimmune diabetes in …

FoxP3+ regulatory T cells (Tregs) protect against autoimmunity, type 1 diabetes (T1D) in
particular, prompting the hypothesis that a deficiency in Tregs is a critical determinant of …