P2X7 is a subtype of ATP-gated channels that is highly expressed in astrocytes, microglia,
and other immune cells. Activation of P2X7 purinoceptors by ATP or 3′-O-(4-benzoyl) …

Background and purpose: P2X7 receptors are ATP‐gated cation channels mediating
important functions in microglial cells, such as the release of cytokines and phagocytosis …

ATP is an important regulator of microglia and its effects on microglial cytokine release are
currently discussed as important contributors in a variety of brain diseases. We here …

Background The ATP-gated ionotropic P2X7 receptor (P2X7R) has the unusual ability to
function as a small cation channel and a trigger for permeabilization of plasmalemmal …

ATP is an important neuronal and astroglial signaling molecule in the brain. In the present
study, brain slices were prepared from the prefrontal cortex (PFC) of Wistar rats and 2 lines …

Among seven members of P2X ionotropic receptors activated by extracellular ATP, the P2X7
subtype is unique in that it can function as a cation channel, a nonselective pore, or even a …

Microglial cells are known to express purinergic receptors for extracellular ATP of both the
P2Y and P2X subtypes. Functional studies have shown that both primary mouse microglial …

Activation of microglia has been implicated in many neurological conditions including
Alzheimer's disease and neuropathic pain. Recent studies provide evidence that P2X ATP …

Previously we demonstrated that ATP released from LPS-activated microglia induced IL-10
expression in a process involving P2 receptors, in an autocrine fashion. Therefore, in the …

P2X receptors are widely distributed in the nervous system, and P2X7 receptors have roles
in neuropathic pain and in the release of cytokines from microglia. They are trimeric …