In the present work, we study the development and biological characterization of a
polymethyl methacrylate (PMMA)-based minocycline delivery system, to be used as a space …

This study aims the in vivo biological characterization of an innovative minocycline delivery
system, based on polymethylmethacrylate bone cement. Bone cements containing 1% or …

The treatment of bone infections still involves systemic or local antibiotic therapy in high
doses for prolonged periods. Current research focuses on the application of different drug …

Currently the safe and responsible use of antibiotics is a world-wide concern as it promotes
prevention of the increasing emergence of multiresistant bacterial strains. Considering that …

Cranioplasty represents the surgical repair of bone defects or deformities in the cranium
arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and …

The treatment of osteomyelitis, a destructive inflammatory process caused by bacterial
infections to bone tissue, is one of the most critical challenges of orthopedics and bone …

The incorporation of antibacterial agents into biomaterials is extremely desirable for
repairing bone defects. Minocycline, a semi-synthetic tetracycline antibiotic, is active against …

The use of a strategy involving space maintenance as the initial step of a two-stage
regenerative medicine approach toward reconstructing significant bony or composite tissue …

The development of infections still represents a severe problem in orthopedic field. In this
work, we developed an anti-microbial and radiopaque calcium phosphate bone cement with …

Antibiotic laden bone cements are regularly employed to prevent infections after joint
replacement surgeries. We have developed silica nanocarriers loaded with gentamicin as a …