COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix
SAG Willis-Owen, A Thompson, PR Kemp, MI Polkey… - Scientific reports, 2018 - nature.com
Skeletal muscle dysfunction is a frequent extra-pulmonary manifestation of Chronic
Obstructive Pulmonary Disease (COPD) with implications for both quality of life and survival …
Obstructive Pulmonary Disease (COPD) with implications for both quality of life and survival …
Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls
RA Rabinovich, E Drost, JR Manning, DR Dunbar… - Respiratory …, 2015 - Springer
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) has significant
systemic effects beyond the lungs amongst which muscle wasting is a prominent contributor …
systemic effects beyond the lungs amongst which muscle wasting is a prominent contributor …
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease
P Lakshman Kumar, AC Wilson… - Journal of cachexia …, 2021 - Wiley Online Library
Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of
death globally. COPD patients with cachexia or weight loss have increased risk of death …
death globally. COPD patients with cachexia or weight loss have increased risk of death …
Differentially co‐expressed myofibre transcripts associated with abnormal myofibre proportion in chronic obstructive pulmonary disease
JW Chiles III, AC Wilson, R Tindal… - Journal of Cachexia …, 2024 - Wiley Online Library
Background Skeletal muscle dysfunction is a common extrapulmonary manifestation of
chronic obstructive pulmonary disease (COPD). Alterations in skeletal muscle myosin heavy …
chronic obstructive pulmonary disease (COPD). Alterations in skeletal muscle myosin heavy …
Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD
E Puig-Vilanova, J Martínez-Llorens, P Ausin… - Clin Sci …, 2015 - portlandpress.com
Epigenetic mechanisms regulate muscle mass and function in models of muscle dysfunction
and atrophy. We assessed whether quadriceps muscle weakness and atrophy are …
and atrophy. We assessed whether quadriceps muscle weakness and atrophy are …
Molecular and biological pathways of skeletal muscle dysfunction in chronic obstructive pulmonary disease
E Barreiro, J Gea - Chronic respiratory disease, 2016 - journals.sagepub.com
Chronic obstructive pulmonary disease (COPD) will be a major leading cause of death
worldwide in the near future. Weakness and atrophy of the quadriceps are associated with a …
worldwide in the near future. Weakness and atrophy of the quadriceps are associated with a …
Established biomarkers of chronic obstructive pulmonary disease reflect skeletal muscle integrity's response to exercise in an animal model of pulmonary emphysema
J Balnis, CE Vincent, AJ Jones, LA Drake… - American Journal of …, 2020 - atsjournals.org
Methods Experiments were conducted using CC10-rtTA-IL-13 (IL13 TG) doxycycline-
inducible transgenic mice that develop chronic lung remodeling reminiscent of pulmonary …
inducible transgenic mice that develop chronic lung remodeling reminiscent of pulmonary …
Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis
AEM Kneppers, RAM Haast… - Journal of cachexia …, 2019 - Wiley Online Library
Background Pulmonary rehabilitation (PR) is a cornerstone in the management of chronic
obstructive pulmonary disease (COPD), targeting skeletal muscle to improve functional …
obstructive pulmonary disease (COPD), targeting skeletal muscle to improve functional …
Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD
D Constantin, MK Menon, L Houchen-Wolloff… - Thorax, 2013 - thorax.bmj.com
Background Skeletal muscle dysfunction is a systemic feature of chronic obstructive
pulmonary disease (COPD), contributing to morbidity and mortality. Physical training …
pulmonary disease (COPD), contributing to morbidity and mortality. Physical training …
Epigenetic mechanisms in respiratory muscle dysfunction of patients with chronic obstructive pulmonary disease
E Puig-Vilanova, R Aguilo, A Rodríguez-Fuster… - PloS one, 2014 - journals.plos.org
Epigenetic events are differentially expressed in the lungs and airways of patients with
chronic obstructive pulmonary disease (COPD). Moreover, epigenetic mechanisms are …
chronic obstructive pulmonary disease (COPD). Moreover, epigenetic mechanisms are …