Manufacturing, quality control, and GLP-grade preclinical study of nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles
J Wang, Z Chen, Z Zhang, M Shen, B Zhao… - Stem Cell Research & …, 2024 - Springer
Background Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have
been shown to alleviate inflammation in acute lung injury (ALI) animal models. However …
been shown to alleviate inflammation in acute lung injury (ALI) animal models. However …
Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles
M Shi, Q Yang, A Monsel, J Yan, C Dai… - Journal of …, 2021 - Wiley Online Library
Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs) turn out to be a
promising source of cell‐free therapy. Here, we investigated the biodistribution and effect of …
promising source of cell‐free therapy. Here, we investigated the biodistribution and effect of …
Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury
A Tieu, DJ Stewart, D Chwastek, C Lansdell… - Stem Cell Research & …, 2023 - Springer
Background Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a
promising cell-free therapy for acute lung injury (ALI). To date, no studies have investigated …
promising cell-free therapy for acute lung injury (ALI). To date, no studies have investigated …
[HTML][HTML] Priming Mesenchymal Stem Cells with Lipopolysaccharide Boosts the Immunomodulatory and Regenerative Activity of Secreted Extracellular Vesicles
A Areny-Balagueró, M Camprubí-Rimblas… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) have
been proposed as an alternative to live-cell administration for Acute Respiratory Distress …
been proposed as an alternative to live-cell administration for Acute Respiratory Distress …
GMP-compliant extracellular vesicles derived from umbilical cord mesenchymal stromal cells: manufacturing and pre-clinical evaluation in ARDS treatment
Abstract Background aims Extracellular vesicles (EVs) represent a new axis of intercellular
communication that can be harnessed for therapeutic purposes, as cell-free therapies. The …
communication that can be harnessed for therapeutic purposes, as cell-free therapies. The …
Extracellular Vesicles Derived from Human Adipose-Derived Mesenchymal Stem Cells Alleviate Sepsis-Induced Acute Lung Injury through a MicroRNA-150–5p …
C Zhao, Q Luo, J Huang, S Su, L Zhang… - ACS Biomaterials …, 2023 - ACS Publications
Extracellular vesicles (EVs) derived from human adipose mesenchymal stem cells
(hADSCs) may exert a therapeutic benefit in alleviating sepsis-induced organ dysfunction by …
(hADSCs) may exert a therapeutic benefit in alleviating sepsis-induced organ dysfunction by …
[HTML][HTML] Mesenchymal stromal cell-derived extracellular vesicles reduce lung inflammation and damage in nonclinical acute lung injury: Implications for COVID-19
Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are bioactive particles that
evoke beneficial responses in recipient cells. We identified a role for MSC-EV in immune …
evoke beneficial responses in recipient cells. We identified a role for MSC-EV in immune …
Effects of mesenchymal stromal cell-derived extracellular vesicles in acute respiratory distress syndrome (ARDS): current understanding and future perspectives
Y Su, H Guo, Q Liu - Journal of leukocyte biology, 2021 - academic.oup.com
Acute respiratory distress syndrome (ARDS) is a devastating and life-threatening syndrome
that results in high morbidity and mortality. Current pharmacologic treatments and …
that results in high morbidity and mortality. Current pharmacologic treatments and …
[HTML][HTML] Extracellular vesicles derived from adipose mesenchymal stem cells alleviate PM2. 5-induced lung injury and pulmonary fibrosis
Y Gao, J Sun, C Dong, M Zhao, Y Hu… - Medical science monitor …, 2020 - ncbi.nlm.nih.gov
Background Exposure to PM2. 5 (fine particulate matter≤ 2.5 μm in aerodynamic diameter)
in air increases the risk of lung injury and pulmonary fibrosis (PF). Extracellular vesicles …
in air increases the risk of lung injury and pulmonary fibrosis (PF). Extracellular vesicles …
[HTML][HTML] Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury
R Zhao, L Wang, T Wang, P Xian, H Wang… - Journal of Controlled …, 2022 - Elsevier
Mesenchymal stem cell-derived small extracellular vesicles (MSC-EVs) are promising
nanotherapeutic agent for pneumonia (bacterial origin, COVID-19), but the optimal …
nanotherapeutic agent for pneumonia (bacterial origin, COVID-19), but the optimal …
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