TGF-β family signaling in tumor suppression and cancer progression

J Seoane, RR Gomis - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …

The dynamic roles of TGF‐β in cancer

E Meulmeester, P Ten Dijke - The Journal of pathology, 2011 - Wiley Online Library
The transforming growth factor‐β (TGF‐β) signalling pathway plays a critical and dual role in
the progression of human cancer. During the early phase of tumour progression, TGF‐β acts …

[HTML][HTML] TGFβ in cancer

J Massagué - Cell, 2008 - cell.com
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan
biology, and its misregulation can result in tumor development. The regulatory cytokine …

Escaping from the TGFβ anti-proliferative control

J Seoane - Carcinogenesis, 2006 - academic.oup.com
Transforming growth factor-β (TGFβ) has a crucial role in tissue homeostasis and disruption
of the TGFβ pathway has been implicated in many human diseases including cancer. As a …

Role of transforming growth factor-β in cancer progression

AJ Galliher, JR Neil, WP Schiemann - Future oncology, 2006 - Taylor & Francis
Invasion and metastasis are the most lethal characteristics of cancer and the leading causes
of cancer-related death. Transforming growth factor (TGF)-β is a multifunctional cytokine that …

The tale of transforming growth factor‐beta (TGFβ) signaling: A soigné enigma

A Chaudhury, PH Howe - IUBMB life, 2009 - Wiley Online Library
Transforming growth factor‐beta (TGFβ) is a secreted cytokine, which intricately controls a
plethora of physiological and pathological processes during development and …

[HTML][HTML] Transforming growth factor-beta (TGF-β) signaling in cancer-A betrayal within

AB Baba, B Rah, GR Bhat, I Mushtaq… - Frontiers in …, 2022 - frontiersin.org
A ubiquitously expressed cytokine, transforming growth factor-beta (TGF-β) plays a
significant role in various ongoing cellular mechanisms. The gain or loss-of-function of TGF …

The dual role of TGFβ in human cancer: from tumor suppression to cancer metastasis

JJ Lebrun - International Scholarly Research Notices, 2012 - Wiley Online Library
The transforming growth factor‐beta (TGFβ) superfamily encompasses widespread and
evolutionarily conserved polypeptide growth factors that regulate and orchestrate growth …

TGFβ signalling: a complex web in cancer progression

H Ikushima, K Miyazono - Nature reviews cancer, 2010 - nature.com
The distortion of growth factor signalling is the most important prerequisite in tumour
progression. Transforming growth factor-β (TGFβ) signalling regulates tumour progression …

TGF-β signaling in cancer

S Gu, XH Feng - Acta biochimica et biophysica Sinica, 2018 - academic.oup.com
Signals from the transforming growth factor-β (TGF-β) superfamily mediate a broad spectrum
of cellular processes and are deregulated in many diseases, including cancer. TGF-β …