Systemic sclerosis

Y Asano - The Journal of dermatology, 2018 - Wiley Online Library
… by the studies on the phenotype of pericytes. In small … cells with pro-angiogenic phenotype,
at higher levels and α-smooth muscle actin, a marker of those cells with angiostatic phenotype

Defining a unified vascular phenotype in systemic sclerosis

Y Allanore, O Distler, M Matucci‐Cerinic… - Arthritis & …, 2018 - Wiley Online Library
… Microcirculation impairment and related vasculopathy are hallmarks of systemic sclerosis
(SSc)… profile or vascular phenotype will be addressed using more robust data in the near future. …

The immunobiology of systemic sclerosis

YS Gu, J Kong, GS Cheema, CL Keen, G Wick… - Seminars in arthritis and …, 2008 - Elsevier
… characterizing SSc T-cell antigens. It is hoped that the identification of some of the key players
in the induction and maintenance of the SSc fibroblast phenotype may yield new disease-…

Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis: correlations with disease severity and phenotypes

A Giovannetti, E Rosato, C Renzi, A Maselli… - Clinical …, 2010 - Elsevier
… We investigated in systemic sclerosis (SSc) patients the T cell homeostasis and its relationship
with the clinical course of the disease. Distribution of peripheral T cell subsets, thymic …

[HTML][HTML] Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype

SK Mathai, M Gulati, X Peng, TR Russell, AC Shaw… - Laboratory …, 2010 - Elsevier
… /pro-Col-Iα + cells in the blood of healthy aged controls compared with that of patients with
SSc-ILD, we sought to more accurately phenotype the CD45 + /pro-Col-Iα + cells found in the …

T and NK cell phenotypic abnormalities in systemic sclerosis: a cohort study and a comprehensive literature review

I Almeida, SV Silva, AR Fonseca, I Silva… - Clinical reviews in …, 2015 - Springer
cells, CD4+ and CD8+ T cell subsets, total NK cells, and CD56+low and CD56+high NK cell
… + and CD56+ T cells, as well as in NK cells, suggesting that these cells may play a relevant …

[HTML][HTML] The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFβ and IFNγ distinguishes SSc phenotypes

TRDJ Radstake, L van Bon, J Broen, A Hussiani… - PloS one, 2009 - journals.plos.org
cell phenotypes, IFNγ and TGFβ. Because there are two clinically distinct forms of systemic
sclerosis and at least one of these forms evolves over time, we evaluated Th17 cell frequency …

The pathogenesis of systemic sclerosis

EP Stern, CP Denton - Rheumatic Disease Clinics, 2015 - rheumatic.theclinics.com
… The disease is broadly divided by clinical phenotypes, which … proteins and different SSc
phenotypes are strongly associated … The SSc phenotype includes demonstrable abnormalities in …

Distinctive association of peripheral immune cell phenotypes with capillaroscopic microvascular patterns in systemic sclerosis

S Kubo, S Nakayamada, Y Miyazaki… - …, 2019 - academic.oup.com
… Immunological abnormalities in systemic sclerosis patients … Tfh-dominant immune cell
phenotype in systemic sclerosis … immune cell phenotypes between patients with systemic sclerosis

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

C Chizzolini, E Raschi, R Rezzonico… - … : Official Journal of …, 2002 - Wiley Online Library
… Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence
of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has …