… driving tau pathology. b | If Aβ truly drives tau pathology, we might expect these pathologies
… However, Aβ and tau pathology initially develop in very different brain regions, which seems …

… tau expression in a transgenic model where there is concurrent amyloid-β plaque formation
can still reduce tau pathology … taken advantage of the regulatable tau transgene in APP/PS1 …

… tauopathies that display tau pathology independent of amyloid plaque pathology. However,
the … Aβ plaques favor an environment for tau pathology and once tau pathology initiates, it is …

… tau pathology caused by Aβ in the absence of any demonstrable effects on Aβ caused by
excess mutant tau. … Evidence that tau pathology is not just an epiphenomenon of Aβ pathology, …

… shown that there is an intense crosstalk between Aβ and tau proteins. Aβ aggregates
inside and outsides of neurons and intra-neuronal hyper-phosphorylated tau induce dendritic …

… amyloid cascade and particularly Aβ-induced Tau-pathology, which is the focus of this review.
We here discuss available models that recapitulate Aβ-induced Tau-pathology … amyloid …

… To assess the ability of CSF and plasma GFAP markers to predict amyloid-β and tau pathology,
we used two different approaches: one based on regions of interest and the other based …

… Yet this “amyloid cascade hypothesis” has yielded no AD therapeutic benefits in 25 … the tau
pathology is weak and circumstantial, it has become progressively clearer that the amyloid-β …

… effects involve modulation of the amyloid β-peptide (Aβ) and tau. Using in vitro … amyloid
precursor protein (APP) and β-APP cleaving enzyme. Additionally, glucocorticoids augment tau …

… wild-type tau (such as the ALZ17 strain) do normally not produce tau filaments nor do they
… that the tau pathology has been transmitted as a spreading of tau pathology was found from …