… In this review, we aim to reposition the study of transcription factor biology in its historical
context … strategies to develop pharmacological manipulation of transcription factors, focusing on …

… Our understanding of the role of transcription factors in skeletal muscle vastly exceeds
our ability to manipulate this class of proteins for therapeutic benefit. Transcription factors …

… FOXO proteins are transcription factors that are involved in … Therefore, pharmacological
manipulation of FOXO proteins is … pharmacological approaches to modulate FOXO function. …

… Considering the large body of evidence now published in this area, we propose that
pharmacologically manipulating specific aspects of the translational machinery may reverse key …

… The pharmacological modulation of transcription factor … known classes of transcription
factors are largely regulated … cascades that alter transcription factor phosphorylation and …

… This suggests that pharmacological manipulation of specific histone acetylation status is
a potentially useful approach for the treatment of inflammatory diseases. Identification of the …

… Transcription factor p53 transactivates a number of proapoptotic proteins from the … factors
from the mitochondrial intermembrane space. p53 may also induce apoptosis in a transcription-…

… transcription factors, which promote specific gene expression. Recent studies linking WNT
signalling and pluripotency have shown that the human NANOG gene is regulated through a …

… drugs targeting transcription factors of the … ), pharmacological manipulation of transcription
factors using Ehrlich's classic magic-bullet concept 4 remains elusive, and transcription factors …

… of transcription factors in human diseases and we discuss emerging pharmacological
strategies to modulate transcription factor … for their targeting involve manipulation of the complex …