Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine

AL Vincent, W Ma, KM Lager, BH Janke, RJ Webby… - Vaccine, 2007 - Elsevier
In the US, despite available swine influenza virus (SIV) vaccines, multiple influenza
subtypes as well as antigenic and genetic variants within subtypes continue to circulate in …

Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine

JA Richt, P Lekcharoensuk, KM Lager… - Journal of …, 2006 - Am Soc Microbiol
Swine influenza viruses (SIV) naturally infect pigs and can be transmitted to humans. In the
pig, genetic reassortment to create novel influenza subtypes by mixing avian, human, and …

Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine

AL Vincent, KM Lager, BH Janke, MR Gramer… - Veterinary …, 2008 - Elsevier
Two US swine influenza virus (SIV) isolates, A/Swine/Iowa/15/1930 H1N1 (IA30) and
A/Swine/Minnesota/00194/2003 H1N2 (MN03), were evaluated in an in vivo vaccination and …

Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine-associated …

AL Vincent, W Ma, KM Lager, JA Richt… - Journal of …, 2012 - Am Soc Microbiol
Control of swine influenza A virus (IAV) in the United States is hindered because inactivated
vaccines do not provide robust cross-protection against the multiple antigenic variants …

Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs

AL Vincent, JR Ciacci-Zanella, A Lorusso, PC Gauger… - Vaccine, 2010 - Elsevier
The gene constellation of the 2009 pandemic A/H1N1 virus is a unique combination from
swine influenza A viruses (SIV) of North American and Eurasian lineages, but prior to April …

Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs

MA Kappes, MR Sandbulte, R Platt, C Wang, KM Lager… - Vaccine, 2012 - Elsevier
The diversity of contemporary swine influenza virus (SIV) strains impedes effective
immunization of swine herds. Mucosally delivered, attenuated virus vaccines are one …

[HTML][HTML] Efficacy of swine influenza A virus vaccines against an H3N2 virus variant

JH Lee, MR Gramer, HS Joo - Canadian journal of veterinary …, 2007 - ncbi.nlm.nih.gov
We compared the efficacy of 3 commercial vaccines against swine influenza A virus (SIV)
and an experimental homologous vaccine in young pigs that were subsequently challenged …

[HTML][HTML] Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines

A Nogales, K Huang, C Chauché, ML DeDiego… - Virology, 2017 - Elsevier
Abstract Canine Influenza Virus (CIV) H3N8 is the causative agent of canine influenza, a
common and contagious respiratory disease of dogs. Currently, only inactivated influenza …

Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza

J Steel, AC Lowen, L Pena, M Angel… - Journal of …, 2009 - Am Soc Microbiol
Due to the high mortality associated with recent, widely circulating strains of H5N1 influenza
virus in poultry, the recurring introduction of H5N1 viruses from birds to humans, and the …

Attenuated influenza virus vaccines with modified NS1 proteins

JA Richt, A García-Sastre - Vaccines for pandemic influenza, 2009 - Springer
The development of reverse genetics techniques allowing the rescue of influenza virus from
plasmid DNA has opened up the possibility of inserting mutations into the genome of this …