hemodynamic parameters correlate poorly with LVM in humans3, 33, 34 and the rat. 35–37
Although limited, there are compelling examples of genes that have been identified through …

Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and
failure. To determine how strain influences the transcriptional response to pressure overload …

The cardiac extracellular matrix is a dynamic structural support network that is both
influenced by, and a regulator of, pathological remodeling and hypertrophic growth. In …

Following a pathological insult, the adult mammalian heart undergoes hypertrophic growth
and remodeling of the extracellular matrix. Although a small subpopulation of …

Cardiac muscle (the myocardium) is a unique arrangement of atria and ventricles that are
spatially and electrically separated by a fibrous border. The spirally-arranged myocytes in …

The adult mammalian heart has a low intrinsic capacity for regeneration following damage.
As a consequence, myocardial infarction (MI) results in substantial myocyte loss, which is …

After myocardial infarction (MI), the heart's reparative response to the ischemic insult and the
related loss of cardiomyocytes involves cardiac fibrosis, in which the damaged tissue is …

Background and purpose Periostin, a matricellular protein, plays an important role in cardiac
development and remodeling. Its expression profile and the association with myocardial …

Adult mammalian hearts respond to injury with scar formation and not with cardiomyocyte
proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may …

BACKGROUND: Maladaptive left ventricular hypertrophy (LVH) remains a prevalent and
highly morbid condition associated with end-stage heart disease. Originally evaluated in the …