Epigenetic modulation of chromatin states constitutes a vital component of the cellular
repertoire of transcriptional regulatory mechanisms. The development of new technologies …

Background Methylation at cytosines (mCG) is a well-known regulator of gene expression,
but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied …

Epigenetics pertains to heritable alterations in genomic structural modifications without
altering genomic DNA sequence. The studies of epigenetic mechanisms include DNA …

Background Cellular differentiation is marked by temporally and spatially coordinated gene
expression regulated at multiple levels. DNA methylation represents a universal mechanism …

Eukaryotic DNA is organized as a nucleoprotein polymer termed chromatin with
nucleosomes serving as its repetitive architectural units. Cellular differentiation is a dynamic …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is important in developing and post-mitotic cells in various tissues. Recent
studies have shown that DNA methylation is highly dynamic, and plays important roles …

Epigenetic variation is implicated in a range of non-communicable diseases, including those
of the eye. However, investigating the role of epigenetic variation in central tissues, such as …

Epigenetics pertains to heritable alterations in gene expression that do not involve
modification of the underlying genomic DNA sequence. Historically, the study of epigenetic …

The past decade has witnessed rapid advances in our understanding of the biochemistry of
“epigenetics,” as exemplified by the articles in this minireview series. Epigenetics is usually …