[HTML][HTML] The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition

J Kalinina, K Dutta, D Ilghari, A Beenken, R Goetz… - Structure, 2012 - cell.com
Uncontrolled fibroblast growth factor (FGF) signaling can lead to human malignancies
necessitating multiple layers of self-regulatory control mechanisms. Fibroblast growth factor …

[HTML][HTML] Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid

S Ono, M Hane, K Kitajima, C Sato - Journal of Biological Chemistry, 2012 - ASBMB
Polysialic acid (polySia) is a unique polysaccharide that modifies neural cell adhesion
molecule (NCAM) spatiotemporally. Recently, we demonstrated that polySia functions as a …

Growth factor–extracellular matrix interactions regulate wound repair

TA Wilgus - Advances in wound care, 2012 - liebertpub.com
Background: Wound healing is a process made up of several phases, including hemostasis/
inflammation, proliferation, and scar formation/remodeling. An array of growth factors is …

Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands

R Goetz, M Ohnishi, X Ding, H Kurosu… - … and cellular biology, 2012 - Taylor & Francis
It has been recently established that Klotho coreceptors associate with fibroblast growth
factor (FGF) receptor tyrosine kinases (FGFRs) to enable signaling by endocrine-acting …

[HTML][HTML] Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity

R Xu, A Ori, TR Rudd, KA Uniewicz, YA Ahmed… - Journal of Biological …, 2012 - ASBMB
The functions of a large number (> 435) of extracellular regulatory proteins are controlled by
their interactions with heparan sulfate (HS). In the case of fibroblast growth factors (FGFs) …

The structural biology of the FGF19 subfamily

A Beenken, M Mohammadi - Endocrine FGFs and Klothos, 2012 - Springer
The ability of the Fibroblast Growth Factor (FGF) 19 subfamily to signal in an endocrine
fashion sets this subfamily apart from the remaining five FGF subfamilies known for their …

Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction: A Biological Rheostat for Fibroblast Growth Factor 2–Mediated Angiogenesis

D Leali, A Inforzato, R Ronca, R Bianchi… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Angiogenesis is regulated by the balance between pro-and antiangiogenic
factors and by extracellular matrix protein interactions. Fibroblast growth factor 2 (FGF2) is a …

Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis

SL Jan, M Hayashi, Z Kasza, I Eriksson… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Heparan sulfate proteoglycans regulate key steps of blood vessel formation. The
present study was undertaken to investigate if there is a functional overlap between heparan …

FGF21 mutants and uses thereof

EJ Belouski, MM Ellison, AE Hamburger… - US Patent …, 2012 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
42455356&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

FGF23/Klotho axis: phosphorus, mineral metabolism and beyond

J Donate-Correa, M Muros-de-Fuentes… - Cytokine & growth factor …, 2012 - Elsevier
In this work we summarizes the steps that allowed the identification of the fibroblast growth
factor (FGF) 23/Klotho axis as the principal regulator of phosphate homeostasis, exerting …