All the information to make a complete, fully functional living organism is encoded within the
genome of the fertilized oocyte. How is this genetic code translated into the vast array of …

The first cell fate decisions during mammalian development establish tissues essential for
healthy pregnancy. The mouse has served as a valuable model for discovering pathways …

The past few years have marked significant anniversaries in signal transduction, including
the identification of classic growth factors and morphogens, the notion of protein modification …

▪ Abstract Signaling between cells is a widely used mechanism by which cell fate and tissue
patterning is determined in development. We review the mechanisms by which signaling …

During development, signaling pathways specify cell fates by activating transcriptional
programs in response to extracellular signals. Extensive studies in the past 30 years have …

Cell plasticity: Flexible arrangement | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

The formation of a complex multicellular organism from a single cell is one of the most
amazing processes of biology. Embryonic development is characterized by the careful …

Seven major cell–cell signaling pathways—Wnt, TGF-ß, Hedgehog (Hh), receptor tyrosine
kinase (RTK), nuclear receptor, Jak/STAT, and Notch—control the vast majority of cell fate …

Cell proliferation and differentiation are highly coordinated processes during development.
Recent studies have revealed that this coordination may result from dual functions residing …

The exquisitely beautiful form of a developing embryo is the result of a coordination between
the driving forces of morphogenesis and the processes of cell growth, proliferation …