Abstract According to the World Health Organization, a fertile man typically has a sperm
count of 15 million per milliliter of semen. This spermatogenic capacity is determined by …

As the central component of canonical TGFbeta superfamily signaling, SMAD4 is a critical
regulator of organ development, patterning, tumorigenesis, and many other biological …

SUMMARY SMAD4 is the central component of canonical signaling in the transforming
growth factor beta (TGFβ) superfamily. Loss of Smad4 in Sertoli cells affects the expansion …

Bone morphogenetic proteins (BMPs), members of the transforming growth factor‐β
superfamily, extensively influence events that establish male fertility, affecting germ cells and …

Although previous studies have shown that members of the transforming growth factor β
(TGFβ) family are expressed in the seminiferous tubules, the functions of these growth …

The establishment and maturation of the testicular Sertoli cell population underpins adult
male fertility. These events are influenced by hormones and endocrine factors, including …

The transforming growth factor β (TGFβ) family has critical roles in the regulation of fertility. In
addition, the pathogenesis of some human cancers is attributed to misregulation of TGFβ …

Members of the transforming growth factor-β (TGF-β) superfamily play a variety of important
roles in testicular development and function. The tumor suppressor gene, Smad4, is a …

Members of the transforming growth factor beta type (TGFβ) superfamily and their receptors
are expressed in the testis, and are believed to play important paracrine and autocrine roles …

It has now been a decade since the first discovery of the intracellular Smad proteins, the
downstream signalling molecules of one of the most important growth factor families in the …