The gastrointestinal tract is lined by a series of epithelia that share functional requirements
but also have distinct, highly specialized roles. Distinct populations of somatic stem cells …

The gastrointestinal (GI) tract of metazoans is lined by a series of regionally distinct epithelia.
To maintain structure and function of the GI tract, regionally diversified differentiation of …

In the adult Drosophila midgut the bone morphogenetic protein (BMP) signaling pathway is
required to specify and maintain the acid-secreting region of the midgut known as the …

Stem cells are maintained in a specialized microenvironment called niche but the nature of
stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal …

Many adult organs rely on resident stem cells to maintain homeostasis. Upon injury, stem
cells increase proliferation, followed by lineage differentiation to replenish damaged cells …

Adult stem cells vary widely in their rates of proliferation. Some stem cells are constitutively
active, while others divide only in response to injury. The mechanism controlling this …

Maintaining tissue homeostasis is a critical process during infection and inflammation.
Tissues with a high intrinsic turnover, such as the intestinal epithelium, must launch a rapid …

Drosophila has long been an excellent model organism for studying stem cell biology.
Notably, studies of Drosophila's germline stem cells have been instrumental in developing …

Although much is known about injury-induced signals that increase rates of Drosophila
melanogaster midgut intestinal stem cell (ISC) proliferation, it is largely unknown how ISC …

The speed of stem cell differentiation has to be properly coupled with self-renewal, both
under basal conditions for tissue maintenance and during regeneration for tissue repair …