The acquisition of flight contributed to the success of insects and winged forms are present
in most orders. Key to understanding the origin of wings will be knowledge of the earliest …

Cell fate decisions in the early Drosophila wing disc assign cells to compartments (anterior
or posterior and dorsal or ventral) and distinguish the future wing from the body wall (notum) …

The subdivision of the Drosophila wing imaginal disc into dorsoventral (DV) compartments
and limb-body wall (wing-notum) primordia depends on Epidermal Growth Factor Receptor …

Signaling by the Drosophila EGF receptor (DER) is modulated by four known EGF-like
proteins: the agonists Vein (Vn), Spitz (Spi), and Gurken (Grk) and the antagonist Argos …

Signaling through the Drosophila EGF receptor (DER) is important for the growth and
differentiation of the wing. These processes may be mediated by different DER ligands …

Arthropod and vertebrate limbs develop from secondary embryonic fields. In insects, the
wing imaginal disk is subdivided early in development into the wing and notum subfields …

Dpp, a member of the BMP family, is a morphogen that specifies positional information in
Drosophila wing precursors. In this tissue, Dpp expressed along the anterior-posterior …

Growth and patterning of the Drosophila wing disc depends on the coordinated expression
of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in …

The presence of a single EGF receptor in Drosophila is contrasted by multiple ligands
activating it. This work explores the role of two ligands, Spitz and Vein, in the embryonic …

Endoderm induction in Drosophila is mediated by the extracellular signals Decapentaplegic
(Dpp) and Wingless (Wg). We discovered a secondary signal with a permissive role in this …