The wnt signaling pathway plays important roles in development and in many diseases.
Recently several reports suggest that non-canonical Wnt proteins contribute to the …

Acute myocardial infarction induces activation of the acute phase response and infiltration of
leukocytes to the infarcted area. Moreover, myocardium that is remote from ischemic area …

Viral myocarditis (VM) is an important cause of heart failure (HF) in children and adults.
However, the molecular determinants involved in cardiac inflammation and cardiomyocyte …

Rationale: Myocardial infarction causes irreversible tissue damage, leading to heart failure.
We recently discovered that canonical Wnt signaling and the Wnt10b ligand are strongly …

Wnt signaling is dysregulated in heart failure (HF) and may promote cardiac hypertrophy,
fibrosis, and inflammation. Blocking the Wnt ligand Wnt5a prevents HF in animal models …

Aims Overexpression of therapeutic genes with potential disease-limiting effects, specifically
at the site of inflammation, remains a major clinical challenge. In this study, we investigate …

Background Hemodynamic overload causes cardiac hypertrophy leading to heart failure.
Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related …

The Wnt family of secreted glycoproteins participates in a wide array of biological processes,
including cellular differentiation, proliferation, survival, apoptosis, adhesion, angiogenesis …

Background Acute myocardial infarction (AMI)-induced excessive myocardial fibrosis
exaggerates cardiac dysfunction. However, serum Wnt2 or Wnt4 level in AMI patients, and …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …