Anecdotes like those about women who receive a diagnosis of late-stage leiomyosarcoma
after morcellation of fibroids can skew risk perception, leading to estimates of outcomes' …

For decades, statisticiansandclinicianshavedebatedthe meaning of statistical and clinical
significance. In general, mostjournalsremainmarriedtothefrequentist… to statistical testing …

On 30 November 2017, a collaborative action between the US Food and Drug
Administration (FDA) and the Centers for Medicare and Medicaid Services (CMS) …

In a forthcoming chapter in the proceedings of a seminar on the extension of systematic
reviews to diverse study designs, Petticrew and Egan comment that:''There is a widespread …

OVERVIEW OF OVERDIAGNOSIS Extensive evidence indicates that overdiagnosis occurs
in many cancers3; although difficult to quantify, the proportion is substantial. Autopsy …

Cancer places a heavy burden on healthcare systems. The cost of cancer drugs is
increasing, driven largely by the introduction of new, ever more innovative cancer …

Background Expensive drugs for rare diseases (ie orphan drugs) often do not meet
traditional cost-effectiveness criteria and thus put further strain on limited healthcare …

Scott D. Ramsey jnci. oxfordjournals. org JNCI| Editorials 1743 the treatment on survival,
value that period of survival, and then compare it with the cost of treatment. For example, in …

Personalized medicine—the precept that the treatment of disease is most effective when the
definition of both the disease and the treatment is individualized at the patient level—is …

Barrett Rollins, MD, PhD, chief scien-tific officer at the Dana-Farber Cancer Institute, tells an
anecdote to illustrate the promise of “precision medicine.” A 35-year-old patient at Dana …