Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by
loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical …

Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disease
caused by loss-of-function mutations in the ADA2 gene. DADA2 typically presents in …

Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disease
caused by loss-of-function variants in the ADA2 gene. DADA2 typically presents in …

In this issue of the Journal of Leukocyte Biology, Watanabe et al. 1 provide us with novel
insights into the pathophysiology of ADA2 deficiency (DADA2). DADA2 is a rare autosomal …

Abstract Deficiency of ADA2 (DADA2) is the first molecularly described monogenic vasculitis
syndrome. DADA2 is caused by biallelic hypomorphic mutations in the ADA2 gene that …

Human adenosine deaminase 1 deficiency was described in the 1970s to cause severe
combined immunodeficiency. The residual adenosine deaminase activity in these patients …

Deficiency of Adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disorder
presenting with a broad spectrum of clinical manifestations, including immunodeficiency …

Background Adenosine deaminase 2 (ADA2) is a homodimeric, extracellular enzyme and
putative growth factor that is produced by cells of the myeloid lineage and, catalytically …

Deficiency of adenosine deaminase 2 (DADA2) was first described as a monogenic form of
systemic vasculitis that closely resembles polyarteritis nodosa (PAN). The phenotypic …

Deficiency of adenosine deaminase type 2 (DADA2) is an autosomal recessive disease
caused by bi-allelic loss-of-function mutations in ADA2. Treatment with anti-TNF is effective …