Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Rationale: Chronic hypoxia induces pulmonary vascular remodeling, pulmonary
hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms …

Accepted 8 April 2009 ''… as we know, there are known knowns; there are things we know
we know. We also know there are known unknowns; that is to say we know there are some …

Cystic fibrosis (CF) is an inherited disorder caused by a deleterious mutation in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene. Given that the CFTR protein is …

Chronic lung disease (CLD) is often complicated by chronic pulmonary vascular changes
and pulmonary hypertension (PH) in young children. Current therapies for severe PH in …

Primary persistent hyperinsulinaemic hypoglycaemia is characterised by clinical symptoms
that occur when blood glucose levels drop below the normal range. Diazoxide treatment …

ETHNOPHARMACOLOGICAL RELEVANCE: San-Huang-Xie-Xin-Tang (SHXT), composed
of Coptidis rhizoma, Scutellariae radix and Rhei rhizoma, is traditionally used to treat …

Pulmonary hypertension is rare in chronic respiratory diseases but has a strong impact on
the prognosis and is partly underlined by factors other than hypoxaemia. The aim of the …

Information concerning the effects of genetic variation between different background strains
on hemodynamic, morphometric, and gene expression response to hypoxia would be …

INTRODUCTION: Adenotonsillar hypertrophy is a common condition in pediatric patients
with upper respiratory airways complaints, and pulmonary arterial hypertension (PAH) may …