Foundations and implications of astrocyte heterogeneity during brain development and disease

AL Schober, LE Wicki-Stordeur, KK Murai… - Trends in …, 2022 - cell.com
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent
technological advances have revealed unprecedented levels of astrocyte diversity …

Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes

JA Stogsdill, CC Harwell… - Annals of the New York …, 2023 - Wiley Online Library
Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Comparative transcriptomics reveals human-specific cortical features

NL Jorstad, JHT Song, D Exposito-Alonso, H Suresh… - Science, 2023 - science.org
The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Astrocyte Regulation of Synapse Formation, Maturation, and Elimination

WS Chung, KT Baldwin… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Astrocytes play an integral role in the development, maturation, and refinement of neuronal
circuits. Astrocytes secrete proteins and lipids that instruct the formation of new synapses …

Astrocyte–synapse interactions and cell adhesion molecules

M Saint‐Martin, Y Goda - The FEBS journal, 2023 - Wiley Online Library
Astrocytes are increasingly gaining attention as a major player in regulating brain functions.
Not only are astrocytes important for their supporting roles in maintaining optimal neuronal …

Cell adhesion molecules regulating astrocyte–neuron interactions

CX Tan, C Eroglu - Current opinion in neurobiology, 2021 - Elsevier
A tripartite synapse comprises a neuronal presynaptic axon and a postsynaptic dendrite,
which are closely ensheathed by a perisynaptic astrocyte process. Through their structural …

Astrocyte-synapse interactions during brain development

KLG Farizatto, KT Baldwin - Current Opinion in Neurobiology, 2023 - Elsevier
Bidirectional communication between astrocytes and neurons is essential for proper brain
development. Astrocytes, a major glial cell type, are morphologically complex cells that …

Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11. 2 deletion female mice

J Ju, X Li, Y Pan, J Du, X Yang, S Men, B Liu… - Molecular …, 2024 - nature.com
Non-invasive brain stimulation therapy for autism spectrum disorder (ASD) has shown
beneficial effects. Recently, we and others demonstrated that visual sensory stimulation …

Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model

K Saito, E Shigetomi, Y Shinozaki, K Kobayashi… - Brain, 2024 - academic.oup.com
Alexander disease (AxD) is an intractable neurodegenerative disorder caused by GFAP
mutations. It is a primary astrocyte disease with a pathological hallmark of Rosenthal fibres …

The function of astrocytes and their role in neurological diseases

WQ Yuan, WP Huang, YC Jiang, H Xu… - European Journal of …, 2023 - Wiley Online Library
Astrocytes have countless links with neurons. Previously, astrocytes were only considered a
scaffold of neurons; in fact, astrocytes perform a variety of functions, including providing …