The error rate displayed during template copying to produce viral RNA progeny is a
biologically relevant parameter of the replication complexes of viruses. It has consequences …

Poxviruses, of which vaccinia virus is the prototype, are a large family of double-stranded
DNA viruses that replicate exclusively in the cytoplasm of infected cells. This physical and …

Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …

The World Health Organization declared mpox (or monkeypox) a public health emergency of
international concern in July 2022, and prophylactic and therapeutic measures are in urgent …

Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins
for DNA replication and gene expression. Hairpin ends link the two strands of the linear …

Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine, HPMPC] is an acyclic
nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus …

Poxviruses replicate in cytoplasmic structures called factories and each factory begins as a
single infecting particle. Sixty-years ago Cairns predicted that this might have effects on …

Monkeypox (Mpox) is a global health emergency. Yeh et al. analyze tandem repeats and
linkage disequilibrium in monkeypox virus (MPXV) sequences from the 2022 pandemic to …

Genetic recombination is used as a tool for modifying the composition of poxvirus genomes
in both discovery and applied research. This review documents the history behind the …

Ribonucleotide reductases (RRs) are evolutionarily-conserved enzymes that catalyze the
rate-limiting step during dNTP synthesis in mammals. RR consists of both large (R1) and …