Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …

Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that
antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Before osteocytes were recognized as active essential bone cells necessary for bone health,
it was assumed that all the action took place on the bone surface and not within the bone …

The bone marrow niche is a dynamic and complex microenvironment that can both regulate,
and be regulated by the bone matrix. Within the bone marrow (BM), mesenchymal stromal …

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …