Antiphospholipid syndrome (APS) is an autoimmune thrombophilia propelled by circulating
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …

The most frequent and feared complication of paroxysmal nocturnal hemoglobinuria (PNH)
is thrombosis. Recent research has demonstrated that the complement and coagulation …

First described in the early 1980s, antiphospholipid syndrome (APS) is a unique form of
acquired autoimmune thrombophilia in which patients present with clinical features of …

Platelets participate in a variety of responses of the blood to injury. An emerging body of
evidence suggests that these cells express an intrinsic capacity to interact with and trigger …

Tobacco smoke extracts prepared from both mainstream and sidestream smoking have
been associated with heightened platelet activation, aggregation, adhesion, and …

Dysregulation of lymphocyte function, accumulation of autoantibodies and defective
clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic …

C1q is a versatile innate immune molecule that serves as the initiation subcomponent of the
classical complement pathway. In addition, it is also a potent pattern recognition molecule …

Pregnancy poses a challenge for the immune systems of placental mammals. As fetal
tissues are semi-allogeneic and alloantibodies that commonly develop in the mother, the …

The complement system, an arm of the innate immune system plays a critical role in both
health and disease. The complement system is highly complex with dual possibilities …

The role of the complement system in immune thrombocytopenic purpura (ITP) is not well
defined. We examined plasma from 79 patients with ITP, 50 healthy volunteers, and 25 …