Recombinant protein vaccines, a proven approach against coronavirus pandemics
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are
still waiting for a vaccine to become available. The initial focus of accelerated global …
still waiting for a vaccine to become available. The initial focus of accelerated global …
[HTML][HTML] Recent developments in bioprocessing of recombinant proteins: expression hosts and process development
NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …
humans worldwide. The production of therapeutic proteins for treating diseases at large …
[HTML][HTML] A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory
disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a …
disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a …
[HTML][HTML] A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant
C He, J Yang, W Hong, Z Chen, D Peng, H Lei… - Nature …, 2022 - nature.com
The recently emerged Omicron (B. 1.1. 529) variant has rapidly surpassed Delta to become
the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and …
the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and …
Thirty years of baculovirus–insect cell protein expression: from dark horse to mainstream technology
MM Van Oers, GP Pijlman… - Journal of General …, 2015 - microbiologyresearch.org
In December 1983, a seminal paper appeared on the overexpression of human IFN-β in
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …
insect cells with a genetically engineered baculovirus. The finding that baculoviruses …
A brief reminder of systems of production and chromatography‐based recovery of recombinant protein biopharmaceuticals
B Owczarek, A Gerszberg… - BioMed research …, 2019 - Wiley Online Library
Recombinant proteins are produced for various applications in laboratory and industrial
settings. Among them, therapeutic applications have evolved into a mature field in recent …
settings. Among them, therapeutic applications have evolved into a mature field in recent …
[HTML][HTML] Strategies for glycoengineering therapeutic proteins
K Dammen-Brower, P Epler, S Zhu, ZJ Bernstein… - Frontiers in …, 2022 - frontiersin.org
Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a
long-established, substantial role in the safety and pharmacokinetic properties of this …
long-established, substantial role in the safety and pharmacokinetic properties of this …
[HTML][HTML] Genetic engineering of baculovirus-insect cell system to improve protein production
M Hong, T Li, W Xue, S Zhang, L Cui… - … in Bioengineering and …, 2022 - frontiersin.org
The Baculovirus Expression Vector System (BEVS), a mature foreign protein expression
platform, has been available for decades, and has been effectively used in vaccine …
platform, has been available for decades, and has been effectively used in vaccine …
The recombinant expression systems for structure determination of eukaryotic membrane proteins
Y He, K Wang, N Yan - Protein & cell, 2014 - academic.oup.com
Eukaryotic membrane proteins, many of which are key players in various biological
processes, constitute more than half of the drug targets and represent important candidates …
processes, constitute more than half of the drug targets and represent important candidates …
[HTML][HTML] The emergency response capacity of plant-based biopharmaceutical manufacturing-what it is and what it could be
D Tusé, S Nandi, KA McDonald, JF Buyel - Frontiers in Plant Science, 2020 - frontiersin.org
Several epidemic and pandemic diseases have emerged over the last 20 years with
increasing reach and severity. The current COVID-19 pandemic has affected most of the …
increasing reach and severity. The current COVID-19 pandemic has affected most of the …