As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and
functional changes after organ injury. These changes in macrophage phenotype and …

As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …

CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …

TcpC is a multifunctional virulence factor of Uropathogenic Escherichia coli (UPEC).
Macrophages can differentiate into two different subsets M1 and M2 that play distinct roles in …

Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune cell
types in the tumor microenvironment (TME), account for approximately 50% of the local …

The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF),
remains challenging as current available antifibrotic agents are not effective in halting …

Respiratory diseases are the cause of millions of deaths annually around the world. Despite
the recent growth of our understanding of underlying mechanisms contributing to the …

Pulmonary fibrosis (PF) is the pathological change of end-stage interstitial lung diseases
with high mortality and limited therapeutic options. Lung macrophages have distinct subsets …

In mammals, ovarian function is dependent on the primordial follicle pool and the rate of
primordial follicle activation determines a female's reproductive lifespan. Ovarian ageing is …

Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …