Recent advances in neuroinflammation prevention and therapy: the role of natural products and underlying mechanisms based on molecular targets

MM Zhao, JY Duan, Y Shen, Y Liu… - British Journal of …, 2024 - Wiley Online Library
Neuroinflammation is initiated in response to a variety of endogenous and exogenous
sources. As the resident macrophages of the central nervous system, the polarization of …

Microglial gp91phox-mediated neuroinflammation and ferroptosis contributes to learning and memory deficits in rotenone-treated mice

L Tian, P Tang, J Liu, Y Liu, L Hou, J Zhao… - Free Radical Biology and …, 2024 - Elsevier
Apart from dopaminergic neurotoxicity, exposure to rotenone, a commonly used insecticide
in agriculture, also adversely affects hippocampal and cortical neurons, resulting in cognitive …

The optimization design of macrophage membrane camouflaging liposomes for alleviating ischemic stroke injury through intranasal delivery

T Liu, Y Wang, M Zhang, J Zhang, N Kang… - International Journal of …, 2024 - mdpi.com
Ischemic stroke is associated with a high mortality rate, and effective treatment strategies are
currently lacking. In this study, we aimed to develop a novel nano delivery system to treat …

Acacetin targets STING to alleviate the destabilization of the medial meniscus-induced osteoarthritis in mice

D Xu, L Zhang, C Song, D Zhang, C Xing, J Lv… - Naunyn-Schmiedeberg's …, 2024 - Springer
Osteoarthritis (OA) is a common joint disorder affecting about 7% of the global population,
primarily characterized by the gradual loss of articular cartilage. This degeneration results …

Torpor-like Hypothermia Induced by A1 Adenosine Receptor Agonist: A Novel Approach to Protect against Neuroinflammation

K Fu, C Hui, X Wang, T Ji, X Li, R Sun, C Xing… - International Journal of …, 2023 - mdpi.com
Hypothermia is a promising clinical therapy for acute injuries, including neural damage, but
it also faces practical limitations due to the complexities of the equipment and procedures …

FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury

FF Zhong, B Wei, GX Bao, YP Lou, ME Wei… - Neurotoxicity …, 2024 - Springer
This study elucidates the molecular mechanisms by which FABP3 regulates neuronal
apoptosis via mitochondrial autophagy in the context of cerebral ischemia-reperfusion (I/R) …

[HTML][HTML] Xanthoangelol alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia

W Wang, B Ma, Z Li, C Zhong, L Liu, Y Zhou… - … Traditional Medicine and …, 2024 - Elsevier
Background Local inflammation induced by microglial activation plays a significant role in
the pathological process of cerebral ischemia. Angelica keiskei (Miq.) Koidz., a traditional …

Dose-response relationship between C-reactive protein/albumin ratio and in-hospital mortality in elderly patients with acute ischemic stroke

MLYCZ Chenc, LWW Xiec, YZLWL Liud, HZP Weia - 2023 - karger.com
Introduction: The C-reactive protein/albumin ratio is a reliable indicator of outcome risk in
several diseases. This study aims to evaluate prognostic power of the C-reactive …