[HTML][HTML] Molecular implications of HOX genes targeting multiple signaling pathways in cancer
Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a
crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the …
crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the …
[HTML][HTML] Hox genes and evolution
SM Hrycaj, DM Wellik - F1000Research, 2016 - ncbi.nlm.nih.gov
Hox proteins are a deeply conserved group of transcription factors originally defined for their
critical roles in governing segmental identity along the antero-posterior (AP) axis in …
critical roles in governing segmental identity along the antero-posterior (AP) axis in …
Comparative genomic analysis of collagen gene diversity
Collagen gene family, comprising 30% of the total protein mass in mammals, is the major
part of extracellular matrix. To understand the complexity of collagen gene family, detailed …
part of extracellular matrix. To understand the complexity of collagen gene family, detailed …
[HTML][HTML] HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis
X Li, TK Ma, P Wang, H Shi, S Hai, Y Qin, Y Zou… - Cell Death & …, 2024 - nature.com
In chronic kidney disease (CKD), renal fibrosis is an unavoidable result of various
manifestations. However, its pathogenesis is not yet fully understood. Here, we revealed the …
manifestations. However, its pathogenesis is not yet fully understood. Here, we revealed the …
[HTML][HTML] Linking vertebrate gene duplications to the new head hypothesis
L Ray, D Medeiros - Biology, 2023 - mdpi.com
Simple Summary Neural crest cells are unique to vertebrates and migrate long distances
throughout the embryo and give rise to many cell and tissue types, including bone, cartilage …
throughout the embryo and give rise to many cell and tissue types, including bone, cartilage …
[HTML][HTML] Role of two modules controlling the interaction between SKAP1 and SRC kinases comparison with SKAP2 architecture and consequences for evolution
L Levillayer, C Brighelli, C Demeret, A Sakuntabhai… - Plos one, 2024 - journals.plos.org
SRC kinase associated phosphoprotein 1 (SKAP1), an adaptor for protein assembly, plays
an important role in the immune system such as stabilizing immune synapses …
an important role in the immune system such as stabilizing immune synapses …
[HTML][HTML] Frequent promoter methylation of HOXD10 in endometrial carcinoma and its pathological significance
F Yang, D Liu, Y Deng, J Wang, S Mei… - Oncology …, 2020 - spandidos-publications.com
Abstract Homeobox D 10 (HOXD10) is important in cell differentiation and morphogenesis
and serves as a tumor suppressor gene (TSG) in a number of malignancies. The present …
and serves as a tumor suppressor gene (TSG) in a number of malignancies. The present …
[HTML][HTML] Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals
N Pervaiz, N Shakeel, A Qasim, R Zehra… - BMC Evolutionary …, 2019 - Springer
Background The hypothesis that vertebrates have experienced two ancient, whole genome
duplications (WGDs) is of central interest to evolutionary biology and has been implicated in …
duplications (WGDs) is of central interest to evolutionary biology and has been implicated in …
Origin and Evolution of Two Independently Duplicated Genes Encoding UDP- Glucose: Glycoprotein Glucosyltransferases in Caenorhabditis and Vertebrates
DA Caraballo, LI Buzzi, CP Modenutti… - G3: Genes …, 2020 - academic.oup.com
UDP-glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the
gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein …
gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein …
HOX genes as transcriptional and epigenetic regulators during tumorigenesis and their value as therapeutic targets
Several HOX genes are aberrantly expressed in a wide range of cancers interfering with
their development and resistance to treatment. This seems to be often caused by alterations …
their development and resistance to treatment. This seems to be often caused by alterations …