Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Small-cell lung cancer (SCLC) is an aggressive lung cancer subtype and its first-line
treatment has remained unchanged for decades. In recent years, immunotherapy has …

During an inflammatory process, shift in the cellular metabolism associated with an increase
in extracellular acidification are well-known features. This pH drop in the inflamed tissue is …

Metabolic reprogramming is a malignant phenotype of cancer. Cancer cells utilize glycolysis
to fuel rapid proliferation even in the presence of oxygen, and elevated glycolysis is coupled …

Lactate, traditionally regarded as a metabolic waste product at the terminal of the glycolysis
process, has recently been found to have multifaceted functional roles in metabolism and …

During the inflammatory response, macrophage phenotypes can be broadly classified as
pro-inflammatory/classically activated “M1”, or pro-resolving/alternatively “M2” …

The intestinal tract of animals is a complex ecosystem in which nutrients, microbiota and
host cells interact extensively. Probiotics can be considered as part of the natural microbiota …

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases
include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and …

Bioactive substances such as probiotics are becoming a research hotspot in the field of
tissue regeneration due to their excellent regulatory functions. Here, we proposed to load …

Background Lactate has long been considered an intermediate by-product of glucose
metabolism. However, in recent years, accumulating evidence reveals that lactate has …