The field of pediatric neurogastroenterology and motility encompasses some of the most
common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders …

The neural-crest-derived enteric nervous system (ENS) is the intrinsic nervous system of the
gastrointestinal (GI) tract and controls all gut functions, including motility. Lack of ENS …

Hirschsprung disease (HSCR), one of several neurocristopathies in children, is
characterized by nerve loss in the large intestine and is mainly treated by surgery, which …

Background Enteric neuropathies, which result from abnormalities of the enteric nervous
system, are associated with significant morbidity and high health-care costs, but current …

Neurointestinal diseases cause significant morbidity and effective treatments are lacking.
This study aimes to test the feasibility of transplanting autologous enteric neural stem cells …

Introduction Gastrointestinal (GI) motility disorders comprise a wide range of different
diseases affecting the structural or functional integrity of the GI neuromusculature. Their …

The goal of this study was to determine if transplantation of enteric neural stem cells
(ENSCs) can rescue the enteric nervous system (ENS), restore gut motility, reduce colonic …

Objective Hirschsprung disease (HSCR) is one of the common neurocristopathies in
children, which is associated with at least 20 genes and involves a complex regulatory …

Endogenous peptides, bioactive agents with a small molecular weight and outstanding
absorbability, regulate various cellular processes and diseases. However, their role in the …

Hirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in
severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy …