The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

Gram-negative bacterial infections are accompanied by inflammation and somatic or
visceral pain. These symptoms are generally attributed to sensitization of nociceptors by …

Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …

TRPA1 functions as an excitatory ionotropic receptor in sensory neurons. It was originally
described as a noxious cold-activated channel, but its cold sensitivity has been disputed in …

Cold hypersensitivity is the hallmark of oxaliplatin‐induced neuropathy, which develops in
nearly all patients under this chemotherapy. To date, pain management strategies have …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …

The sensation of cold or heat depends on the activation of specific nerve endings in the skin.
This involves heat‐and cold‐sensitive excitatory transient receptor potential (TRP) channels …