Iron is an essential metal for cellular metabolism. The reduced form of iron is a cofactor in
numerous redox reactions in the cell and is therefore required for many vital physiological …

Abstract Objectives Doxorubicin (Dox) belongs to the anthracycline drug classification and is
a widely administered chemotherapeutic. However, Dox use in therapy is limited by its …

Osteosarcoma has been the most common malignant bone tumor in children and
adolescents, while the 5‐y survival of osteosarcoma patients gained no significant …

As lung cancer remains the leading cause of cancer deaths globally, characterizing the
tumor molecular profiles is crucial to tailoring treatments for individuals at advanced stages …

There are limited options for patients who develop liver metastasis from colorectal cancer
(CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has …

Glioma is a common primary tumor of the central nervous system (CNS), with glioblastoma
multiforme (GBM) being the most malignant, aggressive, and drug resistant. Most drugs are …

Patients with estrogen receptor-positive (ER+) breast cancer, the most common subtype,
remain at risk for lethal metastatic disease years after diagnosis. Recurrence arises partly …

Background Colorectal cancer (CRC) is one of the most common malignant tumors of the
digestive system, ranking third for morbidity and mortality worldwide. At present, no effective …

Iron, an essential trace element, plays a complex role in tumour biology. While iron causes
cancer clearance through toxic free radical generation, iron‐induced free radical flux also …

Cancer incidence and mortality are rapidly growing, with liver cancer being the sixth most
diagnosed cancer worldwide and the third leading cause of cancer death in 2020. A number …