Phthalates are commonly used as plasticizers in the manufacturing of flexible polyvinyl
chloride products. Large production volumes of phthalates and their widespread use in …

Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is
within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

BACKGROUND Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and
heterogeneous endocrine disorder in women of reproductive age. Although patients with …

The cellular elements lining the internal surface and inside the cyst The environment around
the endometriotic cyst† Conclusions and future research background: Clinical data suggest …

In recent years, exciting progress has been made towards unravelling the complex
intraovarian control mechanisms that, in concert with systemic signals, coordinate the …

Environmental factors during fetal development can induce a permanent epigenetic change
in the germ line (sperm) that then transmits epigenetic transgenerational inheritance of adult …

Follicular growth and oogenesis involve highly dynamic changes in morphogenesis,
chromatin structure, and gene transcription. The tight coordination of these events leads to …

Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of
ovarian activity before the age of 40 and characterized by amenorrhea (primary or …

In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally
responsible for triggering the indifferent gonads to develop as testes rather than ovaries …