In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …

DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two
important heterochromatin-enriched marks that frequently cooperate in silencing repetitive …