[HTML][HTML] Regulatory role of m6A epitranscriptomic modifications in normal development and congenital malformations during embryogenesis
Y Yao, P Liu, Y Li, W Wang, H Jia, Y Bai, Z Yuan… - Biomedicine & …, 2024 - Elsevier
The discovery of N6-methyladenosine (m 6 A) methylation and its role in translation has led
to the emergence of a new field of research. Despite accumulating evidence suggesting that …
to the emergence of a new field of research. Despite accumulating evidence suggesting that …
[HTML][HTML] Gestational α-ketoglutarate supplementation ameliorates arsenic-induced hepatic lipid deposition via epigenetic reprogramming of β-oxidation process in …
QH Qian, YP Song, Y Zhang, H Xue, WW Zhang… - Environment …, 2024 - Elsevier
Inorganic trivalent arsenic (iAs Ⅲ) at environmentally relevant levels has been found to
cause developmental toxicity. Maternal exposure to iAs Ⅲ leads to enduring hepatic lipid …
cause developmental toxicity. Maternal exposure to iAs Ⅲ leads to enduring hepatic lipid …
Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting TET2-mediated DNA hydroxymethylation reprogramming of HNF4α …
X Peng, H Li, D Wang, L Wu, J Hu, F Ye… - Journal of Hazardous …, 2024 - Elsevier
Exposure to arsenic during gestation has lasting health-related effects on the developing
fetus, including an increase in the risk of metabolic disease later in life. Epigenetics is a …
fetus, including an increase in the risk of metabolic disease later in life. Epigenetics is a …
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner
H Zhang, Q Chen, H Han, C Guo, X Jiang, Y Xia… - Journal of Hazardous …, 2024 - Elsevier
Abstract N6-methyladenosine (m6A) is the most common form of internal post-transcriptional
methylation observed in eukaryotic mRNAs. The abnormally increased level of m6A within …
methylation observed in eukaryotic mRNAs. The abnormally increased level of m6A within …
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice
X Li, G Li, S Cui, Y Hou, Z Li, Z Yan, T Huang… - Food and Chemical …, 2024 - Elsevier
Arsenic exposure is a significant risk factor for folate-resistant neural tube defects (NTDs),
but the potential mechanism is unclear. In this study, a mouse model of arsenic-induced …
but the potential mechanism is unclear. In this study, a mouse model of arsenic-induced …
The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification
J Wang, X Guo, Y Chen, W Zhang, J Ren, A Gao - Toxicology, 2024 - Elsevier
Benzene exposure leads to hematotoxicity, and epigenetic modification is considered to be
a potential mechanism of benzene pathogenesis. As a newly discovered post-transcriptional …
a potential mechanism of benzene pathogenesis. As a newly discovered post-transcriptional …
[PDF][PDF] Urinary Arsenic Metabolism and Birth Outcomes in Tacna, Peru
D Fano-Sizgorich, M Gribble, C Vásquez-Velásquez - Education - journals.uclpress.co.uk
Arsenic exposure during pregnancy might affect foetal development. Arsenic metabolism
may modulate the potential damage to the foetus. Tacna has the highest arsenic exposure …
may modulate the potential damage to the foetus. Tacna has the highest arsenic exposure …